2026 NFL schedule release, betting, lines: Odds for every game this season

The 2026 NFL schedule release is finally here and the schedule will be released in its entirety tonight, but we already know some matchups — and therefore some odds for games.

The Seattle Seahawks will open the season on Wednesday, Sept. 9, hosting the New England Patriots in a Super Bowl LX rematch. The Seahawks are 4.5-point favorites.

There is an ever increasing slate of international games — nine in total this season — including the first-ever NFL game played in Australia between the San Francisco 49ers and Los Angeles Rams. The game is on Thursday, Sept. 10 at 8:35 p.m. ET and the Rams are 2.5-point favorites.

We also know the Thanksgiving games — headlined by Josh Allen’s Buffalo Bills hosting Patrick Mahomes’ Kansas City Chiefs as 2.5-point favorites on Thursday night — and that we have the NFL’s first-ever Thanksgiving Eve game between the Green Bay Packers and Los Angeles Rams.

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Here are the odds at sportsbooks for every NFL game this season that has been confirmed (spread is the first number in parentheses and game total is the second):

Week 1

New England Patriots at Seattle Seahawks (-4.5, 45.5)

San Francisco 49ers vs. Los Angeles Rams (-2.5, 49.5) in Melbourne, Australia

Dallas Cowboys (-2.5, 47.5) at New York Giants

Denver Broncos at Kansas City Chiefs (-2.5, 42.5)

Week 2

Detroit Lions at Buffalo Bills (-3, 52.5)

Week 3

Baltimore Ravens (-2.5, 50.5) at Dallas Cowboys in Rio de Janeiro, Brazil

Week 4

Indianapolis Colts at Washington Commanders (-1.5, 48.5) in London, England

Week 5

Philadelphia Eagles (-2.5, 44.5) vs. Jacksonville Jaguars in London, England

Week 6

Houston Texans (-1.5, 41.5) vs. Jacksonville Jaguars in London, England

Week 7

Pittsburgh Steelers at New Orleans Saints (-2.5, 42.5) in Paris, France

Week 9

Cincinnati Bengals (-4.5, 48.5) vs. Atlanta Falcons (-4.5, 48.5) in Madrid, Spain

Week 10

New England Patriots at Detroit Lions (-1.5, 48.5) in Munich, Germany

Week 11

Minnesota Vikings at San Francisco 49ers (-3.5, 46.5) in Mexico City, Mexico

Week 12 (Thanksgiving)

Green Bay Packers at Los Angeles Rams (-3.5, 49.5)

Chicago Bears at Detroit Lions (-2.5, 53.5)

Philadelphia Eagles at Dallas Cowboys (-1.5, 49.5)

Kansas City Chiefs at Buffalo Bills (-2.5, 50.5)