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Astros vs. Guardians prediction, odds, time: 2026 MLB picks for Monday, April 20 from proven model
TL;DR
The Houston Astros face the Cleveland Guardians on April 20, 2026, with the Guardians favored at -115. The game starts at 6:10 p.m. ET, and the over/under is set at 7.5 runs.
Key points
- Astros have a record of 8-15.
- Guardians have a record of 13-10.
- Astros lost four consecutive games.
- Guardians won their last game against Baltimore, 8-4.
- First pitch is at 6:10 p.m. ET.
Houston AstrosCleveland GuardiansSpencer ArrighettiSlade Cecconi
Imagn Images
American League potential contenders will meet on Monday's MLB schedule as the Houston Astros visit the Cleveland Guardians. Houston (8-15) has dropped four in a row, including getting swept by St. Louis at home over the weekend. Cleveland (13-10) is coming off back-to-back victories, last defeating Baltimore, 8-4, on Sunday. Spencer Arrighetti (1-0, 1.50 ERA) will make his second start of the year for Houston, while Slade Cecconi (0-2, 5.03 ERA) makes his fifth start for the Guardians.
First pitch is at 6:10 p.m. ET from Progressive Field in Cleveland. The Guardians have defeated Houston in four straight meetings. The latest Guardians vs. Astros odds list Cleveland as the -115 favorite on the money line (risk $115 to win $100), while the over/under for total runs is 7.5. Before making any Astros vs. Guardians picks or MLB predictions, be sure to see the Guardians vs. Astros predictions and betting advice from SportsLine's proven computer model.
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The SportsLine Projection Model simulates every MLB game 10,000 times. It was a profitable 35-29 on top-rated MLB money-line picks last season. It also excelled making home run prop picks in 2025, returning nearly 30 units of profit. Anybody following its MLB betting picks at sportsbooks and on betting sites could have seen strong returns.
Q&A
What time does the Astros vs. Guardians game start on April 20, 2026?
The game starts at 6:10 p.m. ET.
What are the betting odds for the Astros vs. Guardians game?
The Guardians are favored at -115 on the money line.
Who are the starting pitchers for the Astros and Guardians?
Spencer Arrighetti will start for the Astros, while Slade Cecconi will start for the Guardians.
How have the Guardians performed against the Astros recently?
The Guardians have defeated the Astros in four straight meetings.
