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Cubs vs. Diamondbacks prediction, odds, time: 2026 MLB picks for Friday, May 1 from proven model
TL;DR
The Chicago Cubs, riding a 12-3 streak, host the Arizona Diamondbacks on May 1. The Cubs are favored at -140, with a total runs over/under set at 7.
Key points
- Cubs are on a 12-3 run over the last two weeks
- Cubs have the best home record in the National League
- First pitch is scheduled for 2:20 p.m. ET
- Zac Gallen and Colin Rea are the starting pitchers
- Cubs are favored at -140 on the money line
Chicago CubsArizona DiamondbacksZac GallenColin Rea
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The Chicago Cubs are on a 12-3 run over the last two-plus weeks, and look to keep the good times rolling when they host the Arizona Diamondbacks to begin a weekend series Friday. The Cubs (19-12) won the final two games of their three-game set in San Diego, while the D'backs (16-14) lost two of three in Milwaukee, allowing 13 runs in each defeat. The Cubs are 11-5 at Wrigley Field, the best home mark in the National League.
First pitch from historic Wrigley Field in Chicago is set for 2:20 p.m. ET. Zac Gallen (1-1, 3.14 ERA) gets the ball for the Diamondbacks, while the Cubs counter with Colin Rea (3-1, 4.61). Chicago is at -140 on the money line in the latest Diamondbacks vs. Cubs odds (risk $140 to win $100), while the over/under for total runs is at 7 runs. Before making any Cubs vs. Diamondbacks picks, be sure to see the Diamondbacks vs. Cubs predictions and betting advice from SportsLine's proven computer model.
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The SportsLine Projection Model simulates every MLB game 10,000 times. It was a profitable 35-29 on top-rated MLB money-line picks last season. It also excelled making home run prop picks in 2025, returning nearly 30 units of profit. Anybody following itsĀ MLB bettingĀ picks atĀ sportsbooksĀ and onĀ betting sitesĀ could have seen strong returns.
Now, the model has set its sights on Cubs vs. DiamondbacksĀ and just locked in its picks and MLB predictions.Ā . Here are severalĀ Ā and betting lines for Diamondbacks vs. Cubs:
Q&A
What are the betting odds for the Cubs vs. Diamondbacks game on May 1, 2026?
The Cubs are favored at -140 on the money line, while the over/under for total runs is set at 7.
Who are the starting pitchers for the Cubs and Diamondbacks on May 1, 2026?
Zac Gallen will start for the Diamondbacks, and Colin Rea will take the mound for the Cubs.
What is the Chicago Cubs' home record as of May 1, 2026?
The Cubs have an 11-5 home record, which is the best in the National League.
How have the Cubs and Diamondbacks performed recently leading up to their May 1 game?
The Cubs have won 12 of their last 15 games, while the Diamondbacks lost two of three games in Milwaukee.