Free MLB home run picks, odds, predictions for April 25: Shohei Ohtani among top HR prop bets on Saturday

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Saturday is another loaded day of MLB games with all 30 teams taking the diamond across 15 games on Saturday, April, 25. That many games on tap means there are plenty of MLB betting opportunities for bettors, such as MLB home prop bets. We've identified two big-name sluggers who are red-hot in the home run department for our top MLB HR picks of the day.

For even more MLB expert picks and predictions, make sure to see what the SportsLine Projection Model has to say.

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Best home run picks for Saturday, April 25

• Ronald Acuna Jr., Braves (+525)
• Shohei Ohtani, Dodgers (+169)

Ronald Acuna Jr., Braves (+525, BetMGM)

It's surprising to see Acuna off to a cold start, especially considering the Braves have been spectacular in all phases to begin 2026. Atlanta hosts the Phillies this weekend after sweeping them last weekend, and there will be a lot of eyes on this matchup on Saturday because is set to make his first start of the year for Philadelphia. Wheeler, a perennial All-Star and two-time Cy Young runner-up, is back after undergoing surgery late last season. We wouldn't normally be targeting players against Wheeler especially if they're off to a colder start like Acuna is but the 2023 National League MVP has great power numbers against Wheeler, taking him deep four times in 49 career at-bats. No player on Saturday has homered off their opposing starting pitcher more than Acuna has off Wheeler. Add in that Wheeler is making his first start of the year and had a 5.85 ERA in five rehab starts while giving up three home runs in 20 innings and this feels like a good time to target Acuna to go deep.