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Giants vs. Reds prediction, odds, time: 2026 MLB picks for Thursday, April 16 from proven model
TL;DR
The Cincinnati Reds aim for a series sweep against the San Francisco Giants on April 16, 2026, after winning 8-3 in the previous game. The Giants have lost four consecutive road games and are currently 3-5 away this season.
Key points
- Cincinnati Reds aim for series sweep against San Francisco Giants
- Giants lost four straight road games
- First pitch at Great American Ball Park at 12:40 p.m. ET
- Cincinnati is a -129 favorite on the money line
- Over/under set at 8 runs
Cincinnati RedsSan Francisco Giants
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The Cincinnati Reds go for the series sweep when they take on the visiting San Francisco Giants in the last of their three-game set on Thursday. Cincinnati is coming off an 8-3 win over San Francisco on Wednesday. The Giants (86-12), who have lost four straight on the road, are 3-5 on the road this season. The Reds (11-7), who have three of their last four, are 6-5 on their home field.
First pitch from Great American Ball Park in Cincinnati is set for 12:40 p.m. ET. The Giants lead the all-time series 1,237-1,037, but the Reds hold a 6-4 advantage in the last 10. Cincinnati is a -129 favorite on the money line (risk $129 to win $100) in the latest Giants vs. Reds odds, while the over/under, is 8. Before making any Reds vs. Giants picks, or MLB predictions, be sure to see the Giants vs. Reds predictions and betting advice from SportsLine's proven computer model.
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Q&A
What time is the Giants vs. Reds game on April 16, 2026?
The game is scheduled to start at 12:40 p.m. ET.
What are the betting odds for the Giants vs. Reds game?
Cincinnati is a -129 favorite on the money line, while the over/under is set at 8.
How have the Giants performed on the road this season?
The Giants have a record of 3-5 on the road this season and have lost four straight games away from home.
What is the recent head-to-head record between the Giants and Reds?
The Giants lead the all-time series 1,237-1,037, but the Reds have a 6-4 advantage in the last 10 matchups.
