Mariners vs. Cardinals prediction, odds, time: 2026 MLB picks for Saturday's game from proven model

Nick Turchiaro

The Seattle Mariners will look to extend their winning streak to three games when they take on the St. Louis Cardinals in a key interleague matchup on Saturday afternoon. Seattle is coming off a 3-2 win over St. Louis on Friday night. The Mariners (12-15), who have won four of their last six, are 2-8 on the road this season. The Cardinals (14-11), who have dropped two in a row, are 7-6 on their home field.

First pitch from Busch Stadium in St. Louis is set for 2:15 p.m. ET. The Mariners lead the all-time series 15-13, and have won six of the last seven meetings. Seattle is a -149 favorite on the money line (risk $149 to win $100) in the latest Mariners vs. Cardinals odds, while the over/under, is 7.5. Before making any Mariners vs. Cardinals picks, be sure to see the Mariners vs. Cardinals predictions and betting advice from SportsLine's proven computer model.

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The SportsLine Projection Model simulates every MLB game 10,000 times. It was a profitable 35-29 on top-rated MLB money-line picks last season. It also excelled making home run prop picks in 2025, returning nearly 30 units of profit. Anybody following its MLB betting picks at sportsbooks and on betting sites could have seen strong returns.