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The San Diego Padres aim for their eighth consecutive win against the Seattle Mariners tonight at 8:40 p.m. ET. Predictions favor the Mariners to win the series finale with Luis Castillo pitching.
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The red-hot San Diego Padres are looking to extend their win streak to eight as they take on the Seattle Mariners at Petco Park tonight at 8:40 p.m. ET.
However, my Mariners vs Padres predictions have Seattle snatching the series finale, with Luis Castillo on the mound.
Read more for my MLB picks for Thursday, April 16.
The Seattle Mariners lost a 7-6 nail-biter last night and will have Luis Castillo on the mound for tonight's rubber match.
While he’s struggled so far with a 6.92 ERA through three starts, the righty has had lots of success against this red-hot San Diego Padres lineup.
Castillo has held them to a .200 average across 65 at-bats while striking out 23. He’s shut down the likes of Manny Machado, Xander Bogaerts, and Fernando Tatis Jr.
On the other side, Walker Buehler owns a 4.97 ERA, and Seattle’s lineup is hitting .325 against him across 40 at-bats. alone is 5-for-6.
The Mariners vs Padres game is scheduled for 8:40 p.m. ET.
Luis Castillo is the starting pitcher for the Mariners in tonight's game.
The Mariners have a moneyline of -111 for the game against the Padres.
The Padres are looking to extend their win streak to eight games.

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Castillo’s best outing of the season so far was on the road, tossing six shutout innings against the Yankees.
It’s only a matter of time until Castillo finds consistency again. After all, he’s an elite starter, and this outing profiles as the perfect opportunity to deal. The right-hander has also been a bit unlucky with a .429 BABIP and a 3.16 FIP.
While Buehler can be inconsistent, he’s only given up seven earned runs across three appearances. I do think Seattle hits him around a bit, but I’m not expecting them to tag him with a bunch of runs. And even if he is shaky, the Padres boast a Top-5 bullpen (3.04 ERA, 25.6 K%) that can stop the bleeding.
Two of the last three meetings between San Diego and Seattle have also cashed the Under.
Quinn Allen's 2026 Transparency Record
The Seattle Mariners have hit the Team Total Under in 29 of their last 45 away games (+10.25 Units / 19% ROI). Find more MLB betting trends for Mariners vs. Padres.
| Location | Petco Park, San Diego, CA |
| Date | Thursday, April 16, 2026 |
| First pitch | 8:40 p.m. ET |
| TV | Mariners.TV, Padres.TV |
| Mariners starting pitcher | Luis Castillo (0-0, 6.92 ERA) |
| Padres starting pitcher | Walker Buehler (0-1, 4.97 ERA) |
Odds are correct at the time of publishing and are subject to change.
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