The Buffalo Bills will host the Detroit Lions in the first regular-season game at the new Highmark Stadium during NFL Week 2 on Prime Video's Thursday Night Football.
Mentioned in this story
The Buffalo Bills will play the first regular-season game at the new Highmark Stadium in NFL Week 2, hosting the Detroit Lions on Prime Video's Thursday Night Football for their home opener, the league announced.
This preview announcement comes ahead of the full schedule release at 8 p.m. ET on ESPN and NFL Network.
For a franchise that had called their old building home since 1973, this is more than a ribbon-cutting. It's a primetime, national-audience launch of the next chapter for the team and its fans— and one that the league and front office mutually shared interest in showcasing on a global broadcast stage.
Buffalo President of Football Operations and General Manager Brandon Beane has spent this offseason actively bolstering the roster around quarterback Josh Allen by way of free agency and the NFL Draft.
The Bills' new home stadium will make its debut in a featured matchup against a competitive and physical NFC team as the TNF opener, complete with a National prime-time audience.
Dan Campbell's Lions remain one of the NFC's more aggressive rosters in terms of playing style, along with a franchise quarterback in search of a Super Bowl championship as well. Like the Bills, the Lions restocked their roster with an eye on once again competing in the postseason.
Like last year's matchup against the Baltimore Ravens, Detroit provides an early gauge and measuring-stick opponent for Buffalo right off the bat.
It's anything but a soft-open for the team and their new stadium, as they are firmly in the spotlight.
The game is scheduled for NFL Week 2, airing on Thursday Night Football.
It marks the first regular-season game at the new stadium, showcasing a new chapter for the franchise.
Josh Allen is the quarterback for the Buffalo Bills as they prepare for the game.
Girls from the Ninth and 10th Regions have qualified for the KHSAA state tennis tournament. The list of qualifiers highlights the top talent in high school tennis from these regions.
49ers rookie Romello Height can't wait to learn from Nick Bosa
LeBron James' outfit for potential final NBA game turns heads
Don't miss the Giants vs. Dodgers game today at 7:10 p.m. PT!
Lakers may see roster changes as they trail Thunder 3-0 in playoffs
Live updates on Caleb Wilson's 2026 NBA Draft Combine performance!
See every story in Sports — including breaking news and analysis.
The Bills will debut a 2026 roster with a new look and turnover in personnel from last season, in addition to a new coach in former offensive coordinator and quarterbacks coach Joe Brady, and new coordinators across all three phases. Beane's work this offseason, following a promotion and coaching staff change, will also be on display.
The goal is the same, and that is to make it to and win the Super Bowl. The expectations will be that the changes will help the team get over the hump of falling short of that goal in the Division round or the AFC Championship game.
Detroit will travel to face them in Orchard Park on Thursday night, on Prime Video, in a brand-new Highmark Stadium as the football world watches on.
This article originally appeared on Bills Wire: NFL Buffalo Bills Detroit Lions Amazon Prime Video AFC NFC Josh Allen