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The Tennessee Titans' draft history over the past 25 years includes standout picks like Derrick Henry and disappointing selections like Isaiah Wilson. As the NFL draft approaches, the Titans are looking to build on their past successes and address team needs.
The NFL draft is just three days away, and the smokescreens are rising across the league in what could be one of the most unpredictable drafts in recent memory.
The Tennessee Titans will be on the clock early, and at this point, there are way too many variables to truly decipher what they will do with this all-important haul. While they have some holes to fill, they are in a better place than when they kicked off the offseason.
With the next group of rookies preparing to come to Nashville, Bryan DeArdo took a look back at the past 25 drafts and found the best and worst of the Titans' draft classes since the year 2000.
**Tennessee Titans**Best pick: RB Derrick Henry (No. 45 overall, 2016)
After a quiet first two seasons in Nashville, Henry quickly became one of the greatest running backs in NFL history. He won back-to-back rushing titles with the Titans, which included a season that saw him become the eighth player to run beyond 2,000 yards in a season. With the Ravens, Henry had the greatest season in NFL history by a running back over the age of 30 in 2024 when he ran for 1,921 yards.
In 2026, Henry could conceivably pass four running backs to move into sixth place on the NFL's all-time career rushing list.
Worst pick: OT Isaiah Wilson (No. 29 overall, 2020)
Barring injury, not many first-round picks end up playing in just one regular-season NFL game. Discipline issues, however, led to Wilson's career amounting to just one game. He was traded to the Dolphins for a seventh-round pick in 2021 but was released just three days later after showing up late for his physical and missing two workouts.
Landing King Henry in the second round was a homerun. A rare combination of size and speed, he was not only the face of the franchise, but he has also proven to be one of the most dominant backs of his generation.
The best draft pick is Derrick Henry, selected 45th overall in 2016, while the worst is Isaiah Wilson, chosen 29th overall in 2020.
Derrick Henry became one of the greatest running backs in NFL history, winning back-to-back rushing titles and achieving over 2,000 rushing yards in a season.
Isaiah Wilson played only one game for the Titans due to discipline issues and was later traded to the Dolphins, where he was released shortly after.

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As durable and impactful as Henry was, Wilson was the polar opposite, and his selection definitely started the Titans' downward spiral. Wilson flamed out before the Titans even struck the match, and they cannot afford another miss of that caliber.
This article originally appeared on Titans Wire: Tennessee Titans: Best and worst NFL draft picks of last 25 years