
Jorja Aiono and Seren Singleton have been selected for their Test debuts in the opening game against Scotland.
Hannah Dallavalle is set to earn her 70th cap, marking a significant milestone in her international career.
Carys Phillips and Jasmine Joyce have been left out of the match day squad, with Phillips ruled out through injury.

Wales has named uncapped players Jorja Aiono and Seren Singleton for their Women's Six Nations opener against Scotland on Saturday. Kate Williams will captain the team, while former captain Hannah Dallavalle is set to earn her 70th cap.
Sean Lynn has selected two uncapped players for Wales' opening game of the Women's Six Nations against Scotland on Saturday (16:40 BST).
Lock Jorja Aiono and wing Seren Singleton have been given the nod for their Test debuts after impressing for Brython Thunder in the Celtic Challenge.
Kate Williams leads the side, with Alex Callender ruled out of the tournament through injury, while former captain Hannah Dallavalle is set to win her 70th cap.
But there is no place in the match day squad for international regulars Carys Phillips and Jasmine Joyce.
"Jorja and Seren fully deserve this opportunity and have impressed in the Celtic Challenge and in camp," said head coach Lynn.
"Jorja has a real physicality and edge to her game that we need and Seren's work-ethic and willingness to put her body on the line for the cause are the attributes we are looking for."
Williams makes up an experienced back row with Bethan Lewis and Bryonie King.
Gwenllian Pyrs, Kelsey Jones and Sisilia Tuipulotu reunite in the front row, with Gwen Crabb joining Aiono as locks.
Keira Bevan and Lleucu George are the half-backs, with Kayleigh Powell preferred at full-back.
Carys Cox and Courtney Keight are given more time to form a midfield partnership from the World Cup, while Lisa Neumann and Singleton are named on the wings.
Lynn has opted for a six-two split of forwards and backs on the bench, including the experience of Donna Rose, Georgia Evans and Dallavalle.
Wales are looking for their first Six Nations win under Lynn, who has now been in the job for 12 months.
They have finished with the wooden spoon for the past two championships and also endured a disappointing World Cup, bowing at the pool stage last summer.
However, with the introduction of a new backroom staff and nine uncapped players in the squad, Lynn has a clean slate from which to work.
He said: "This is a fresh start for Wales and is the first step for this new group of players, coaches and staff, and we had plenty of debate around the selection of this team.
"The players know we are representing the nation, our families and ourselves and this is an opportunity to show who we are and what it means to wear the red jersey."
Wales: Powell; Singleton, Cox, Keight, Neumann; George; Bevan, G Pyrs, Jones, Tuipulotu, Aiono, Crabb, Lewis, Williams (capt), King.
Replacements: Reardon, Davies, Rose, A Pyrs, Evans, Metcalfe, Lockwood, Dallavalle.
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