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Red Sox vs. Tigers prediction, odds, line, time: 2026 MLB picks for May 4 from proven model
TL;DR
The Boston Red Sox face the Detroit Tigers in a three-game series starting May 4, 2026. The Tigers are favored at -204, while the Red Sox have struggled recently, losing five of their last six games.
Key points
- Red Sox have lost five of six games
- Tigers have won four of five games
- First pitch at 6:40 p.m. ET
- Tigers favored at -204 on the money line
- Payton Tolle vs. Tarik Skubal as starting pitchers
Boston Red SoxDetroit TigersPayton TolleTarik Skubal
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The Boston Red Sox and Detroit Tigers begin a three-game series on Monday, and the teams are heading in opposite directions. Boston (13-21) has lost five of six, averaging just 1.6 runs per game during the slump. Detroit (18-17), meanwhile, has won four of five, with a pitching staff that's given up 1-2 runs in three of four. Left-handers face off on Monday, as Payton Tolle (0-1, 3.38 ERA) goes for the Sox, while the Tigers counter with two-time defending AL Cy Young Award winner Tarik Skubal (3-2, 2.70).
First pitch is at 6:40 p.m. ET from Comerica Park in Detroit. The latest Tigers vs. Red Sox odds list Detroit as the -204 favorite on the money line (risk $204 to win $100), with host Boston priced at +169( risk $100 to win $169). The over/under for total runs is 7. Before making any Red Sox vs. Tigers picks, be sure to see the Tigers vs. Red Sox predictions and betting advice from SportsLine's proven computer model.
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The SportsLine Projection Model simulates every MLB game 10,000 times, and is coming off a 5-0 week on top-rated MLB picks. It also excelled at making home run prop picks in 2025, returning nearly 30 units of profit. Anybody following its MLB betting picks at sportsbooks and on betting sites could have seen strong returns.
Now, the model has set its sights on Red Sox vs. Tigers and just locked in its picks and MLB predictions. You can head to SportsLine now to see the model's picks. Here are several  and betting lines for Tigers vs. Red Sox:
Q&A
What are the odds for the Red Sox vs. Tigers game on May 4, 2026?
The Tigers are favored at -204 on the money line, while the Red Sox are priced at +169.
What time does the Red Sox vs. Tigers game start on May 4, 2026?
The game is scheduled to start at 6:40 p.m. ET.
Who are the starting pitchers for the Red Sox vs. Tigers game on May 4, 2026?
Payton Tolle will start for the Red Sox, while Tarik Skubal will pitch for the Tigers.
How have the Red Sox and Tigers performed recently before their May 4, 2026 matchup?
The Red Sox have lost five of their last six games, while the Tigers have won four of their last five.
