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Yankees vs. Red Sox prediction, odds: 2026 MLB picks for Wednesday's game from proven model
TL;DR
The New York Yankees face the Boston Red Sox on Wednesday, aiming for a fifth consecutive win after defeating Boston 4-0. Max Fried will pitch for the Yankees against Ranger Suarez for the Red Sox, with New York favored at -142.
Key points
- Yankees aim for five-game winning streak
- Yankees defeated Red Sox 4-0 on Tuesday
- Max Fried starts for Yankees, Ranger Suarez for Red Sox
- Yankees are 14-9, Red Sox are 9-14
- Game starts at 6:45 p.m. ET
New York YankeesBoston Red SoxMax FriedRanger Suarez
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The New York Yankees will look to extend their winning streak to five games when they battle the Boston Red Sox in the second of a three-game series on Wednesday night. New York downed Boston 4-0 on Tuesday. The Yankees (14-9), who lead the American League East, are 6-4 on the road this season. The Red Sox (9-14), who have lost three of four, are 5-6 on their home field in 2026. Max Fried (2-1, 2.97 ERA) is on the hill for New York, while Ranger Suarez (1-1, 3.22 ERA) is starting for Boston.
First pitch from Fenway Park in Boston is set for 6:45 p.m. ET.Ā New York is a -142 favorite on the money line (risk $142 to win $100) in the latest Yankees vs. Red Sox odds, while the over/under, is 7.5. Before making any Yankees vs. Red Sox picks, be sure to see the Yankees vs. Red Sox predictions and betting advice from SportsLine's proven computer model.
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The SportsLine Projection Model simulates every MLB game 10,000 times. It was a profitable 35-29 on top-rated MLB money-line picks last season. It also excelled making home run prop picks in 2025, returning nearly 30 units of profit. Anybody following itsĀ MLB bettingĀ picks atĀ sportsbooksĀ and onĀ betting sitesĀ could have seen strong returns.
Q&A
What time does the Yankees vs. Red Sox game start on April 22, 2026?
The game is set to start at 6:45 p.m. ET.
Who are the starting pitchers for the Yankees vs. Red Sox game on April 22, 2026?
Max Fried will pitch for the Yankees, while Ranger Suarez will start for the Red Sox.
What are the latest odds for the Yankees vs. Red Sox game on April 22, 2026?
The Yankees are favored at -142 on the money line, with an over/under of 7.5.
How have the Yankees and Red Sox performed recently leading up to their April 22, 2026 game?
The Yankees are on a four-game winning streak and lead the AL East, while the Red Sox have lost three of their last four games.
